CJC-1295/ Ipamorelin
MECHANISM OF ACTION
CJC-1295 (GHRH analog) drives GH amplitude via GHRH-R; Ipamorelin (GHRP) amplifies GH frequency via ghrelin-R without cortisol or prolactin bleed. The combination produces clean, physiologic GH output while preserving native pituitary feedback loops.
POSSIBLE SIDE EFFECTS
- Mild water retention
- Transient tingling, headache, or flushing
- Possible daytime drowsiness
- Dose dependent and resolves with adjustment
MOTS-c
MECHANISM OF ACTION
16-amino acid mitochondrially encoded peptide (12S rRNA region). Activates AMPK, the master metabolic regulator, shifting substrate utilization toward fat oxidation, improving glucose handling, and upregulating antioxidant defense and mitochondrial biogenesis programs.
POSSIBLE SIDE EFFECTS
- Well tolerated
- Mild injection site reactions possible
- Brief fatigue possible
- Monitor glucose if diabetic or pre diabetic
Semax
MECHANISM OF ACTION
Heptapeptide derived from ACTH(4-7). Potently upregulates BDNF and TrkB expression in the hippocampus, drives neuroplasticity and neurogenesis, and modulates serotonergic, dopaminergic, and adrenergic pathways governing focus and mood.
POSSIBLE SIDE EFFECTS
- Brief nasal irritation (BDNF activation, expected days 1 to 4)
- Mild stimulation initially
- Otherwise well tolerated
Thymosin Aplha-1
MECHANISM OF ACTION
28-amino acid thymic peptide. Enhances dendritic cell antigen presentation via TLR9 activation, improves CD4+/CD8+ T-cell and NK-cell activity, and calibrates adaptive immune responses without inducing autoimmune activation.
POSSIBLE SIDE EFFECTS
- Very well tolerated
- Rare brief injection site reactions
- Occasional mild flu like activation, transient and self limiting
KPV
MECHANISM OF ACTION
C-terminal tripeptide of alpha-MSH. Binds MC1R and MC3R on intestinal epithelial and immune cells, suppressing NF-kB and TNF-alpha signaling to reduce mucosal inflammation locally without measurable systemic immunosuppression.
POSSIBLE SIDE EFFECTS
- Exceptionally well tolerated
- Mild Gl adjustment initially possible
- Systemic side effects uncommon
GHK-Cu
Endogenous copper binding tripeptide. Stimulates collagen, elastin, and fibroblast synthesis, drives angiogenesis, suppresses ROS via antioxidant signaling, and modulates expression of 4,000+ human genes toward youthful, reparative patterns.
POSSIBLE SIDE EFFECTS
- Injection site irritation common
- Local side effects common
- Topical: occasional mild irritation in sensitive individuals
Selank
MECHANISM OF ACTION
Synthetic tuftsin analog. Modulates GABAergic signaling without receptor downregulation, balances serotonergic and dopaminergic tone, and suppresses stress induced pro inflammatory cytokines to produce alert, non sedating anxiolysis.
POSSIBLE SIDE EFFECTS
- Extremely well tolerated
- Mild brief nasal irritation possible
- No sedation, dependence, or withdrawal
TB-500
MECHANISM OF ACTION
Synthetic analog of the Thymosin Beta-4 actin binding domain. Promotes actin polymerization and cell migration, stimulates VEGF mediated angiogenesis, recruits healing cells to injury sites, and acts on hair follicle stem cells for pigmentation support.
POSSIBLE SIDE EFFECTS
- Well tolerated
- Mild injection site reactions possible
- Brief head rush post dose